Centro di Referenza Nazionale (CRN) per l’Antibioticoresistenza

Istituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri
Istituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri

Molecole per infezioni da Enterobacterales (Clinical Breakpoints)

Elenco di possibili molecole antibiotiche per la valutazione della sensibilità in agenti batterici patogeni Enterobacterales isolati nel bovino.
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Beta Lattamici Ampicillina (metrite-bovino) P P P NP NP NP NP NP NP NP NP NP
Ampicillina (HD) P P P P P P NP NP NP NP NP P
Amoxicillina NP NP NP NP NP NP P NP P NP NP P
Amoxicillina + acido clavulanico (HD) P P P P P P P NP P NP NP P*
(Cefazolina) (HD) P P P P P P NP NP NP NP NP P
Cefotaxime NP NP NP P P P NP NP NP NP NP P
Ceftiofur NP NP NP NP NP NP P NP P NP NP P**
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
(Fluoro)chinolonici Enrofloxacin NP NP NP NP NP NP P NP P NP NP P
Ciprofloxacin NP NP NP P P P NP NP NP NP NP NP
Ciprofloxacina E.coli NP NP NP P P P NP NP NP NP NP P
Ciprofloxacina Klebsiella pneumoniae NP NP NP NP NP NP NP NP NP NP NP P
Acido nalidixico/Flumequine NP NP NP NP NP NP P NP P NP NP P
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Aminoglicosidi (Aminociclitoli) Kanamicina (HD) P P P P P P P NP P NP NP P
Gentamicina (HD) P P P P P P P NP P NP NP P
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Amfenicoli Cloramfenicolo§ (HD) P P P P P P P NP P NP NP P
(Florfenicol) NP NP NP NP NP NP P NP P NP NP P
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Sulfonamidi Sulfonamidi NP NP NP NP NP NP P NP P NP NP NP
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Trimethoprim Trimethoprim NP NP NP NP NP NP P NP P NP NP P
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Trimethoprim-sulfamethoxazole Enterobacterales (HD) P NP P P NP P P NP P NP NP P
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Tetracicline Tetracicline NP NP NP P P P P NP P NP NP P
Enterobacterales CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Polimixine (Colistina) Colistina NP NP NP NP P P P NP P NP NP P

Note:

  • P: Clinical breakpoint/Epidemiological cutoff presente
  • NP: Clinical breakpoint/Epidemiological cutoff non presente
  • HD: Human-derived (breakpoints derivati dallo Standard Umano, come da documento CLSI VET)
  • * per E.coli è presente un tentative Ecoff
  • ** per Klebsiella pneumoniae è presente un tentative Ecoff
  • Gli antibiotici tra parentesi sono da considerarsi facoltativi

 


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