Centro di Referenza Nazionale (CRN) per l’Antibioticoresistenza

Istituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri
Istituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri

Molecole per mastiti da Gram positivi (Clinical Breakpoints)

Elenco di possibili molecole antibiotiche per la valutazione della sensibilità in agenti batterici patogeni Gram positivi isolati nel bovino.
Mastiti Gram +vi $ CLSI VET 01S-Ed 6  CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Beta Lattamici Penicillina Staphylococcus spp (HD) P NP P NP NP NP P NP P NP NP NP
Penicillina Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
Penicillina Streptococcus beta haemolytic group (HD) NP NP NP P NP NP P NP P NP NP NP
Penicillina Streptococcus agalactiae NP NP NP NP NP NP NP NP NP NP NP P
Penicillina Streptococcus viridans group (HD) NP NP NP P P P NP NP NP NP NP NP
Penicillina Enterococcus spp P NP P P NP P NP NP NP NP NP P
Cefoxitina^ Staphylococcus spp (HD) P NP P NP NP NP NP NP NP NP NP P
Cefoxitina^ Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
(Ceftiofur) Staphylococcus aureus P P P NP NP NP NP NP NP NP NP P
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
(Fluoro)chinolonici Ciprofloxacina Staphylococcus spp NP NP NP P p P NP NP NP NP NP NP
Ciprofloxacina Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
Enrofloxacina Staphylococcus spp NP NP NP NP NP NP P NP P NP NP NP
Enrofloxacina Streptococcus spp NP NP NP NP NP NP P NP P NP NP NP
Ciprofloxacina Streptococcus agalactiae NP NP NP NP NP NP NP NP NP NP NP P
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Aminoglicosidi (Aminociclitoli) Kanamicina Staphylococcus spp NP NP NP NP NP NP P NP P NP NP NP
Kanamicina Staphylococcus aureus(HD) NP NP NP NP NP NP NP NP NP NP NP P
Gentamicina Staphylococcus spp (HD) P P P P P P P NP P NP NP NP
Gentamicina Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
Gentamicina Streptococcus agalactiae NP NP NP NP NP NP NP NP NP NP NP P
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Lincosamidi Pirlimicina Staphylococcus aureus P NP P NP NP NP NP NP NP NP NP NP
Pirlimicina Streptococcus agalactiae, dysgalactiae, uberis P NP P NP NP NP NP NP NP NP NP NP
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Macrolidi Eritromicina Staphylococcus spp P P P NP NP NP P NP P NP NP NP
Eritromicina Enterococcus spp (HD) P P P NP NP NP NP NP NP NP NP NP
Eritromicina Streptococcus spp (HD) P P P NP NP NP P NP P NP NP NP
Eritromicina Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
Eritromicina Streptococcus agalactiae NP NP NP NP NP NP NP NP NP NP NP P
Eritromicina Streptococcus uberis NP NP NP NP NP NP NP NP NP NP NP P
Eritromicina Streptococcus dysgalactiae NP NP NP NP NP NP NP NP NP NP NP P
Eritromicina Enterococcus faecium/faecalis NP NP NP NP NP NP NP NP NP NP NP P
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Rifaximine Rifampicina Staphylococcus spp (HD) NP NP NP P P P NP NP NP NP NP NP
Rifampicina Enterococcus spp (HD) NP NP NP P P P NP NP NP NP NP NP
Rifampicina Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
Rifampicina Enterococcus faecalis NP NP NP NP NP NP NP NP NP NP NP P
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Sulfonamidi Sulfonamidi Staphylococcus spp NP NP NP NP NP NP P NP P NP NP NP
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Trimethoprim Trimethoprim Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P
Trimethoprim Staphylococcus spp NP NP NP NP NP NP P NP P NP NP NP
Mastiti Gram +vi $ CLSI VET 01S-Ed 6 (HD) CLSI M100 S33 CA-SFM VET 2023 EUCAST ECOFF 2023
S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥ S≤ I (range) R≥
Trimethoprim-sulfamethoxazole Staphylococcus spp (HD) P NP P P NP P P NP P NP NP NP
Streptococcus spp NP NP NP NP NP NP P NP P NP NP NP
Streptococcus agalactiae NP NP NP NP NP NP NP NP NP NP NP P
Streptococcus dysgalactiae NP NP NP NP NP NP NP NP NP NP NP P
Streptococcus uberis NP NP NP NP NP NP NP NP NP NP NP P
Staphylococcus aureus NP NP NP NP NP NP NP NP NP NP NP P

Note:

  • P: Clinical breakpoint/Epidemiological cutoff presente
  • NP: Clinical breakpoint/Epidemiological cutoff non presente
  • HD: Human-derived (breakpoints derivati dallo Standard Umano, come da documento CLSI VET)
  • $ Per Staphyloccus aureus, Streptococcus, altri Gram +vi (Trueperella pyogenes)
  • ^ Per Staphylococcus aureus
  • Gli antibiotici tra parentesi sono da considerarsi facoltativi

 


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